ALS is a rare, progressing disease

Amyotrophic lateral sclerosis (ALS) is a rare, progressing disease in which motor neurons degenerate or die diminishing the signals that control muscle function.

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New publication in the Journal of Cardiovascular Pharmacology: Working hypothesis for mechanisms of action of levosimendan in patients with ALS

A Review article summarizing the Potential of Levosimendan in the Management of ALS: Overview of a Working Hypothesis

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LEVALS study results assessing the effects of oral levosimendan in patients with ALS published

The Phase 2 clinical trial (LEVALS) show encouraging results: in 66 patients supine SVC was significantly higher after 14 days treatment on oral levosimendan compared to placebo.

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Patient trials under way on ALS treatment to support breathing capacity

The REFALS trial is studying the effects of oral levosimendan in patients with amyotrophic lateral sclerosis (ALS).

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Appetite for life

ALS study Webinar

Access Policy for ALS

Orion aims to build well-being in ALS by developing effective new treatments to help patients manage their illness and improve their quality of life.

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ALS – symptoms and treatment

The beginning and progression of ALS symptoms vary between people. The treatment is planned by a multi-professional team in cooperation with the patient. The patients’ families need support as well.

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Orion's R&D Pipeline